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KMID : 1103720120660020139
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Journal of the Korean Society of Radiology
2012 Volume.66 No. 2 p.139 ~ p.147
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Vascular Biocompatibility of a Triple Layered Self Expanding Stent-Graft in a Dog Mode
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Bae Jae-Ik
Won Je-Hwan
Jang Eun-Ho
Lee Sung-Young
Ko Kwang-Tae
Jin Bo-Hwan
Lee Jun-Woo
Kim Ji-Dae
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Abstract
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Purpose: To evaluate performance and biocompatibility of a newly designed self-expanding stent graft, which consisted of two nitinol stents and an intervening expanded polytetrafluoroethylene membrane in a dog artery model.
Materials and Methods : Twelve stent grafts were placed in the aorta of 6 dogs (beagle, mean body weight 11 kg) for 4 weeks (n = 4) and 12 weeks (n = 8). Luminal diameters were measured for each segment (the proximal bare, the middle graft, the distal bare) by angiographies after implantation and follow up periods. Percent luminal stenosis based on angiographies, histomorphometric, histologic, and scanning electron microscopic analyses of each segments were performed.
Results: Blood flow through the stent grafts was good after implantation and during the follow up period, without thrombotic occlusion or stent graft migration. The mean percent luminal stenosis of the proximal bare, the middle grafted and the distal bare segments after 12 weeks were 13.5%, 3.9%, 9.6% retrospectively. The mean neointimal areas of the middle grafted segment were 4.39 mm2 (4 week) and 4.92 mm2 (12 week). Mature endothelialization was evident in over 70% of the area of the stented artery after 4 weeks and in over 90% after 12 weeks.
Conclusion: The stent graft was well placed in the attempted area without migration. During the 12-week-follow up period, it showed a good patency without thrombotic occlusion or significant in-stent luminal stenosis. Endothelialization was rapid and nearly complete. Neointima was thin and smooth on the middle graft segment and thicker and irregular on the bare segments.
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KEYWORD
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Artery, Interventional Procedure, Stent-Graft
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